by NOMIX | June 4, 2024 | BIOCOACH, Medical Interventions, Micronutrition
Rapamycin’s mechanism of action involves inhibiting the mechanistic target of rapamycin (mTOR), a protein kinase that plays a crucial role in regulating cell growth, proliferation, metabolism, and aging. mTOR exists in two distinct complexes, mTORC1 and mTORC2....
by NOMIX | May 25, 2024 | Bioclock
Longevity research has identified three important signaling pathways in the body that slow down the ageing process and promote health. They act as energy and nutrient sensors in the body and react to changes in our cells. Each pathway has its own mechanism that...
by NOMIX | January 26, 2022 | Adversity, Exercise, Wim Hof
In this episode of the Lifespan Podcast, Dr. David Sinclair and Co-host Matthew LaPlante dive deeply into the science of non-dietary interventions that mimic adversity and promote health. They begin by highlighting how different types of physical activity (i.e.,...
by NOMIX | January 20, 2022 | Aging, Diet, Information Theory of Aging
In this episode, Harvard professor Dr. David Sinclair and co-host Matthew LaPlante discuss how frequently we should eat, what food we should avoid, and what food we should pursue. They discuss the science behind how a “low energy state,” which can be...
by NOMIX | January 18, 2022 | Aging, Information Theory of Aging
In this podcast episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (i.e. mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic...
