In this episode of the Lifespan Podcast, Dr. David Sinclair and Co-host Matthew LaPlante dive deeply into the science of non-dietary interventions that mimic adversity and promote health. They begin by highlighting how different types of physical activity (i.e., low-intensity aerobic exercise, high-intensity aerobic exercise, and weight training) protect against age-related disease and enhance longevity.
David and Matthew additionally highlight the latest evidence behind hyperbaric oxygen therapy, cold therapy, and heat therapy. As they discuss different adversity mimetics, they also explain how these interventions influence aging at the molecular and physiological levels.
- A single mutation doubles lifespan in worms
- Extending lifespan in yeast with one mutation
- Daily step count and health outcomes
- Reversing vascular aging in mice
- Aerobic exercise is linked to a lower biological age
- A lifestyle and diet intervention decreases biological age
- An epigenetic clock that predicts time-to-death
- Ultra-cheap age prediction
- Exercise decreases biomarkers of cellular senescence
- Telomere length is increased by hyperbaric oxygen therapy
- Hyperbaric oxygen therapy improves cognitive performance
- A cold temperature promotes longevity in worm
- Sauna bathing, mortality, and cardiovascular risk