Why Do We Age?


January 18, 2022

In this podcast episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (i.e. mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of “ex-differentiation” in which cells begin to lose their identity, and how all of this makes up the “Information Theory of Aging”, and the difference between “biological age” and “chronological age” and how we can measure biological age through DNA methylation clocks.

Weapon fragments in bowhead whales
Rapamycin extends lifespan in mice
Targeting Aging with Metformin (TAME) Trial
Metformin improves healthspan and lifespan in mice
Metformin reduces all-cause mortality
Reprogramming to restore vision
DNA methylation age
Genome-wide methylation profiles & human aging rates
Reversal of epigenetic aging in humans
Danish twins study


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