nomix.ai

Author: NOMIX

  • Exercise, Heat, Cold & Other Adversity Mimetics for Longevity

    In this episode of the Lifespan Podcast, Dr. David Sinclair and Co-host Matthew LaPlante dive deeply into the science of non-dietary interventions that mimic adversity and promote health. They begin by highlighting how different types of physical activity (i.e., low-intensity aerobic exercise, high-intensity aerobic exercise, and weight training) protect against age-related disease and enhance longevity.

    David and Matthew additionally highlight the latest evidence behind hyperbaric oxygen therapy, cold therapy, and heat therapy. As they discuss different adversity mimetics, they also explain how these interventions influence aging at the molecular and physiological levels.


    Links:

  • What To Eat And When For Longevity?

    In this episode, Harvard professor Dr. David Sinclair and co-host Matthew LaPlante discuss how frequently we should eat, what food we should avoid, and what food we should pursue. They discuss the science behind how a “low energy state,” which can be induced by a period of fasting, combats aging and promotes health. They also walk through research that points to the benefits of a mostly plant-based diet for slowing aging and offer key insights into when to eat and what to eat to maximize longevity.

    Links:

    Dietary restriction extends lifespan in dogs – https://bit.ly/3FlDo4y
    Intermittent fasting in patients with metabolic syndrome – https://go.nature.com/3FggKKZ
    Alternate day fasting in healthy, non-obese humans – https://bit.ly/3HXGptH
    Time-restricted feeding in humans with prediabetes – https://bit.ly/3ffZWct
    A 24-hour fast reduces inflammasome activation in humans – https://bit.ly/3fwDc8t
    Fasting and diabetes – https://bit.ly/3rdtRHQ
    Intermittent energy restriction and multiple sclerosis – https://bit.ly/3HV7i1o
    A fasting-mimicking diet in patients with breast cancer – https://go.nature.com/3flcbV2
    Mouse genetics influence how diet affects lifespan – https://bit.ly/3qiBc9R
    Vegetarian dietary patterns and human mortality – https://bit.ly/31OCtMq
    A Mediterranean diet slows biological aging – https://bit.ly/3I1rcbd
    Plant polyphenols regulate lifespan in yeast – https://go.nature.com/3HWWGiB
    A Mediterranean diet is linked to reduced mortality – https://bit.ly/3fdDPDx

  • NOMIX Mission Statement

    When cancer in a patient is suspected, the first line of investigation in most cases is to perform a biopsy, sticking a long needle into the area in question again and again, or punching through the patient’s hip bone in order to extract material for testing. In endoscopic biopsies, a tube is inserted into the body of a patient under anesthesia, to extract material for testing. Analysis of the results takes up to several days and costs thousands of Euros to complete. And, although these are relatively routine procedures, complications take place in as many as 30% of conventional biopsies.

    Creating An Incentive Scheme For Longevity

    The respective diagnostic procedure for cardiovascular disease isn’t much more appealing. If the patient is lucky, she’ll have a chest X-Ray, CT, MRI, echocardiogram, or ECG in the hospital. But she might require a cardiac catheter, i.e. a tube is inserted into an artery in her groin and navigated up toward her heart, in order to flush in a dye that allows X-Ray technicians to get a better look at her heart valves and arteries. This again will cost several thousand Euros.

    Unfortunately, for many other common causes of death like stroke and Alzheimer’s disease, there is simply no effective means of accurate early diagnosis. But a range of new diagnostic methods is beginning to challenge these invasive, expensive, or even non-existent methods. When they are fully developed to scale, these methods will be highly effective and highly affordable.

    DIY Health Diagnostics

    All the data you need to achieve your optimal healthspan is already inside us – in our blood, in our DNA, and in our habits. Unlike our DNA, which reveals our body’s predispositions, but doesn’t change, our blood is dynamic: it reveals how our body changes over time, in response to our diet, exercise, or lifestyle. Your daily habits reveal how you live. 

    Most of us have a digital thermometer, a (body-fat) scale, or a blood pressure gauge at home – those of us already own some basic household diagnostic technology. You are probably familiar with so-called wearables; i.e. wearable health devices like chest strap heart monitors for jogging enthusiasts, or smartwatches, s.a. Apple Watch, or Fitbit, or the Oura ring, which monitors your heart rate, sleep quality, and other personal health metrics. There are home blood tests that monitor your cholesterol and blood glucose, and even home tests that help diagnose STDs, allergies, and food intolerances. 

    Numerous apps leverage your phone’s camera, gyroscope, GPS, and other sensors to provide you with real-time monitoring of relevant organism-related data. Do-It-Yourself DIY health diagnostic devices like these are becoming increasingly wearable, portable, even implantable, ingestible, and – most relevant affordable for individuals. Similar to the development in computer hardware, the latest wearables are equipped with much more computing power than many giant medical devices in hospitals. Besides their general computing performance, they are also adding more and more functionality: Apple Watch now includes blood oxygen level readings and an electrocardiogram (ECG) monitoring function, to help detect atrial fibrillation, the most common heart rhythm disorder. 

    DIY health diagnostic devices are – like small portable computers in the 1990s – on their way to replace incumbent medical technology that requires trained experts and maintenance. In 2022, companies like Apple will launch their Augmented Reality (AR) devices that might be transformed into de facto Brain-Computer Interfaces (BCI), running a real-time computation on brain signals. 

    Another kind of wearables that is available in basic versions is the so-called ‚smart clothing‘. More elaborate products with improved functionality, s.a. artificial skin should become available soon.

    Providing A Continuous, Personalised, Realtime Data Flow

    Working with data collected by DIY health diagnostic devices will prove to be the ultimate way for health diagnostics in general. As soon as the collected data are of the same or similar quality as data collected with medical technology devices in hospitals or medical offices, the health sector, and overall individuals’ health, will experience a paradigm shift: having personalized health data at hand, real-time, allows for much better early diagnosis. 

    And what‘s good for early diagnosis adds perfectly to an individual‘s personal omics, i.e. the holistic molecular, physiological, and environmental profile over time. The analysis of a combination of our blood, DNA, and habitual data is the basis to achieve longevity. Bridging genome and dynamic physiology, detecting diseases at an early stage, and uncovering lifestyles and environmental patterns associated with a (potential / future) disease, is the goal of the NOMIX team. 

    Validated personal omics and biomarkers of aging would allow for testing medical interventions to extend lifespan (and healthspan because changes in the biomarkers would be observable throughout the lifespan of the organism. The uses for personal omics and biomarkers of aging are ubiquitous and identifying a physical parameter of biological aging would allow humans to determine our true age, mortality, and morbidity. 

    Since the change in the physical biomarkers should be proportional to the change in the age of the species, humans will be able to dive into research on extending life- and health spans and finding timelines for the arise of potential genetic disease, based on an AI-powered system that allows for a continuous flow of real-life personal omics data.

    By creating CODIS, the Collective Digital Immune System for Longevity, NOMIX will allow for an unprecedented leap in research and applied biotechnology, improving the overall quality of life, bringing us a much faster good deal closer to longevity, and a 3P-Medicine (preventive, personalized, precision) approach that is not limited to the more prosperous parts of the population.

    Slow aging, optimize your healthspan: Join the NOMIX Longevity movement!

  • Why Do We Age?

    In this podcast episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (i.e. mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of “ex-differentiation” in which cells begin to lose their identity, and how all of this makes up the “Information Theory of Aging”, and the difference between “biological age” and “chronological age” and how we can measure biological age through DNA methylation clocks.

    Links  
Weapon fragments in bowhead whales
Rapamycin extends lifespan in mice
Targeting Aging with Metformin (TAME) Trial
Metformin improves healthspan and lifespan in mice
Metformin reduces all-cause mortality
Reprogramming to restore vision
DNA methylation age
Genome-wide methylation profiles & human aging rates
Reversal of epigenetic aging in humans
Danish twins study

  • Breathing for Mental & Physical Health & Performance

    In this podcast episode, neuroscientist AndrewHuberman is joined by Dr. Jack Feldman, Distinguished Professor of Neurobiology at the University of California, Los Angeles, and a pioneering world expert in the science of respiration (breathing).

    They discuss how and why humans breathe the way we do, the function of the diaphragm and how it serves to increase oxygenation of the brain and body. They also discuss how breathing influences mental state, fear, memory, reaction time, and more. And Dr. Huberman and Dr. Feldman discuss specific breathing protocols such as box-breathing, cyclic hyperventilation (similar to Wim Hof breathing), nasal versus mouth breathing, unilateral breathing, and how these each affect the brain and body. They discuss physiological sighs, peptides expressed by specific neurons controlling breathing, and magnesium compounds that can improve cognitive ability and how they work.

  • Why We Age, And Why We Don’t Have To

    An interview by neuroscientist Andrew Huberman with David Sinclair, Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity.

    In this podcast episode, Andrew Huberman and David Sinclair discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process. They discuss (intermittent) fasting and supplementation with Resveratrol, Metformin, and NMN.

    They also discuss the use of caffeine, exercise, cold exposure, along with food choices for offsetting aging and promoting autophagy, the process of clearing the organism of dead cells. And they discuss the key blood markers everyone should monitor to determine their biological versus chronological age.

    It rarely happens that top scientists talk in easily understandable words and provide such a wealth of useful advice. We therefore strongly recommend listening to or even watching this podcast episode – these two hours might belong to the best investment of your valuable time, ever! Since – who does not want to stop aging?!

    Enjoy!

  • The Rise of DIY Health Diagnostics

    When cancer in a patient is suspected, the first line of investigation in most cases is to perform a biopsy, sticking a long needle into the area in question again and again, or punching through the patient’s hip bone in order to extract material for testing. In endoscopic biopsies, a tube is inserted into the body of a patient under anaesthesia, to extract material for testing. Analysis of the results takes up to several days, and cost thousands of Euros to complete. And, although these are relatively routine procedures, complications take place in as many as 30% of conventional biopsies.

    The respective diagnostic procedure for cardiovascular disease isn’t much more appealing. If the patient is lucky, she’ll have a chest X-Ray, CT, MRI, echocardiogram, or ECG in the hospital. But she might require a cardiac catheter, i.e. a tube is inserted into an artery in her groin and navigated up toward her heart, in order to flush in a dye that allows X-Ray technicians to get a better look at her heart valves and arteries. This again will cost several thousand Euros.

    Unfortunately, for many other common causes of death like stroke and Alzheimer’s disease, there is simply no effective means of accurate early diagnosis. But a range of new diagnostic methods is beginning to challenge these invasive, expensive, or even nonexistent methods. When they are fully developed to scale, these methods will be highly effective and highly affordable.

    Enter Wearables

    Most of us have a digital thermometer, a (body-fat) scale, or a blood pressure gauge at home – those of us already own some basic household diagnostic technology. You are probably familiar with so-called wearables; i.e. wearable health devices like chest strap heart monitors for jogging enthusiasts, or smartwatches, s.a. Apple Watch, or Fitbit, or the Oura ring, which monitor your heart rate, sleep quality, and other personal health metrics. There are home blood tests that monitor your cholesterol and blood glucose, and even home tests that help diagnose STDs, allergies, and food intolerances.

    DIY Health Diagnostics

    Numerous apps leverage your phone’s camera, gyroscope, GPS, and other sensors to provide you with real-time monitoring of relevant organism-related data. Do-It-Yourself DIY health diagnostic devices like these are becoming increasingly wearable, portable, even implantable, ingestible, and – most relevant affordable for individuals. Comparable to the development in computer hardware, the latest wearables are equipped with much more computing power than many giant medical devices in hospitals. Besides their general computiúng performance, they are also adding more and more functionality: Apple Watch now includes blood oxygen level readings and an electrocardiogram (ECG) monitoring function, to help detect atrial fibrillation, the most common heart rhythm disorder. DIY health diagnostic devices are – like small portable computers in the 1990s – on their way to replace incumbent medical technology that requires trained experts and maintenance.

    A Continuous, Personalised, Realtime Data Flow

    Working with data collected by DIY health diagnostic devices will prove as the ultimate way for health diagnostics, in general. As soon as the collected data are of the same or similar quality as data collected with medical technology devices in hospitals or medical offices, the health sector will experience a paradigm shift: having personalised health data at hand, real-time, allows for much better early diagnosis. 

    And what‘s good for early diagnosis adds perfectly to an individual‘s personal omics, i.e. the holistic molecular, physiological, and environmental profile over time. Bridging genome and dynamic physiology, detecting diseases at an early stage, and uncovering lifestyles and environmental patterns associated with a (potential/future) disease, is the goal of the NOMIX team. Building the Collective Digital Immune System CODIS will allow for a 3P-Medicine approach that is not limited to the more prosperous parts of the population.

  • Technical Components of the Collective Digital Immune System CODIS

    The integration of technological advances, specifically in the fields of decentralization and cryptography, provides scientists and entrepreneurs with the tools for transforming a hitherto conceptual approach of the collective digital immune system into a practical application. The Collective Digital Immune System CODIS will be usable by every individual with access to the internet, and health professionals, from scientists to physicians.

    Here’s a summary of CODIS‘ technical components.

    NOMIX Wallet

    The NOMIX Wallet allows for search & discovery, computation on, and billing of CODIS data. It comes with a fully-fledged Self-Sovereign Identity (SSI) functionality: individual and professional users can verifiably authenticate themselves digitally while being in full control of their data. This unique privacy feature supported by Compute-to-Data by Ocean Protocol makes the NOMIX Wallet fully compliant with EU laws and regulations. Integrated EVERKEY and EVERID mechanisms by Datarella allow for secure management of all data and recovery of potentially lost data, s.a. keyphrases (e.g. passwords) even in completely decentralised storage. Additionally, users receive NOMIX Reward tokens in their NOMIX Wallet as rewards for their active participation in creating and maintaining CODIS. This mechanism helps to maintain sustainable overall market growth.

    NOMIX Autonomous Agents

    Individual and professional users can make use of a variety of Autonomous Agents, s.a. Autonomous Privacy Agents (AMA) that autonomously safeguard user data and other data privacy compliant with GDPR, or Autonomous Search Agents (ASA) that search and discover for personal omics data, adding them to CODIS and analyse them in their contexts. Autonomous Agents improve automated data services to a degree that users themselves get a better understanding of their personal omics and how to leverage this knowledge to improve individual and overall health conditions. Autonomous Agents are powered by Fetch.ai technology. In the long-term, Autonomous Agents will help to establish a privacy-preserving data environment, allowing users to pro-actively opt-in receiving personalized recommendations, rather than being targeted by unsolicited push services.

    NOMIX Reward Tokens

    Individual and professional NOMIX users can earn NOMIX ‘Nanos’ for a bunch of different CODIS data activities that can be converted into NOMIX Reward tokens, airdropped to the NOMIX Wallet. Activities include – among others – the provision of personal omics data, creating and sharing algorithms to compute on the CODIS data, etc. NOMIX tokens power the work of Autonomous Agents, i.e. they facilitate the communication between the NOMIX users; s.a. search & discovery, computation on, and billing of CODIS data. Autonomous Search and Privacy Agents will be fed with NOMIX tokens in order to allow for a privacy-preserving search and discovery, and contextualised way of safeguarding CODIS data. Some fraction of the NOMIX fees and Autonomous Agents fees are used to buy back NOMX and burn.

    In short, the NOMIX reward token takes on the function of a lubricant for NOMIX: it rewards and incentivises individual and professional users to provide personal omics data to create and maintain CODIS, and, at the same time, provides a sustainable business model for CODIS-related services – based on a GDPR-compliant, privacy-preserving data management.

  • Building The Collective Digital Immune System CODIS for Longevity

    The immune system is a network of biological processes that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to parasitic worms, as well as cancer cells and objects such as wood splinters, distinguishing them from the organism’s own healthy tissue.

    In the same way as a biological immune system, the Collective Digital Immune System (CODIS) adapts over time, by observing the microbial landscape, detecting potential threats, and neutralizing them before they spread beyond control. This simple strategy – effectively tested over millions of years – can now start to be replicated with the combination of distributed sensor sequencing and applied tools of computation and analysis to the capture and interpretation of biological data (i.e. bioinformatics, or: biomarkers) where a network of autonomous agents acting as sequencing devices serves a real-time stream of microbial personal omics to a collective network for analysis.

    Driven by a shift from single-reference genomics to more quantitative, population-wide analyses of personal omics, biology has moved beyond developing a qualitative understanding of cellular and evolutionary processes towards base-pair resolution and predictive models of biological systems and disease. A combination of improved biotechnology, machine learning algorithms, statistical models, and autonomous agents has been the key driver of this development.

    The integration of other technological advances in the fields of decentralization and cryptography provides scientists and entrepreneurs with the tools for transforming a hitherto conceptual approach into a practical application – the Collective Digital Immune System CODIS for Longevity. At NOMIX, we have been working on this intersection of biotechnology and computer technology and are looking forward to presenting the first version of CODIS in 2022.

  • We are NOMIX

    Hello – this is NOMIX! We‘re building the Collective Digital Immune System CODIS for Longevity!

    We use decentralized artificial intelligence to build a framework for applications to search, discover, and compute on personal omics and biomarker data. By leveraging machine learning, advanced cryptography, and autonomous agents based on a Self-Sovereign Identity (SSI) infrastructure, our blockchain-mediated collective learning system enables individuals and multiple stakeholders in the health sector to build a shared machine learning model without needing to rely on a central authority, and without revealing any datasets to other stakeholders.

    The NOMIX team consists of curious experts in the fields of AI/ML, blockchain technology, cryptography, bioinformatics, bioengineering and company building. Our work is based on the core principles of eco-responsibility, sustainability, transparency, regulatory compliance, scalability, and reliability.