In this week’s Lifespan podcast episode, Harvard Professor Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters, resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine.
Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effects associated with these molecules are additionally highlighted.
Links:
- The Sinclair Lab website
- Nicotinamide riboside is well-tolerated in humans
- Nicotinamide riboside is a sirtuin-activator
- Mice treated with nicotinamide riboside are longer-lived
- Nicotinamide riboside protects mice against obesity
- An inflammatory signature is attenuated by nicotinamide riboside
- Nicotinamide riboside, pterostilbene, and ALS
- Nicotinamide mononucleotide combats diabetes in mice
- Aging is slowed by nicotinamide mononucleotide
- Nicotinamide mononucleotide in prediabetic women
- NAD and cancer in mice
- Resveratrol protects mice against a high-calorie diet
- Resveratrol in patients with type 2 diabetes
- Supplementing resveratrol in metabolic syndrome patients
- Fisetin enhances longevity in mice
- Quercetin and fatty liver disease
- Dasatinib and quercetin decrease senescent cell burden
- Mice fed rapamycin late in life live longer
- Spermidine induces life extension and cardioprotection in mice
- Spermidine and older subjects with cognitive decline
- Healthspan and lifespan in mice are improved by metformin
- Metformin, age-related diseases, and mortality
- Targeting aging with metformin (TAME) trial
- Treating mice with berberine extends lifespan
- Lifespan in fruit flies is prolonged by berberine
- Berberine and metabolic disorders
