You can find high levels of spermidine in foods like fresh peppers, wheat germ, broccoli, cauliflower, and cheese. Soy products like natto, shiitake, and durian also have high amounts of spermidine.

Spermidine has been shown to have many benefits in animal studies. It can help protect the heart and brain and even fight cancer. It’s also been linked to a reduced risk of cancer and heart disease in human studies.

Spermidine works by maintaining the health of our mitochondria, reducing inflammation, and helping stem cells stay healthy. It also helps by mimicking the effects of calorie restriction, which is when you eat fewer calories but still get all the nutrients your body needs.

In animal studies, giving spermidine has been shown to increase the survival rate, improve memory, and even help with motor skills. In human studies, taking spermidine supplements is safe and effective in improving memory and reducing blood pressure.

Here are some of the key details about spermidine and its benefits:

1. Anti-aging effects: Spermidine has been shown to slow down the aging process by promoting autophagy, a process where cells clean up and recycle damaged components. This helps maintain cellular health and prevent age-related diseases.
2. Cardioprotective effects: Spermidine has been found to protect the heart by reducing inflammation, oxidative stress, and blood pressure. It may also help prevent cardiovascular diseases like atherosclerosis and heart failure.
3. Neuroprotective effects: Spermidine has been shown to improve memory, learning, and cognitive function in both animal and human studies. It may also help protect the brain from neurodegenerative diseases like Alzheimer’s and Parkinson’s.
4. Anti-cancer effects: Spermidine has been found to inhibit cancer cell growth and promote cancer cell death. It may also help prevent cancer by reducing inflammation and oxidative stress.
5. Mitochondrial health: Spermidine helps maintain the health of mitochondria, the energy-producing structures within cells. This is important for overall cellular health and may help prevent diseases like diabetes and neurodegenerative disorders.
6. Caloric restriction mimic: Spermidine has been found to mimic the effects of caloric restriction, which is when you eat fewer calories but still get all the nutrients your body needs. This has been shown to have many health benefits, including increased lifespan.
7. Safety and efficacy: Spermidine has been shown to be safe and well-tolerated in human studies, with no significant side effects. It has also been found to be effective in improving various health markers, such as blood pressure, memory, and cognitive function.

In terms of dietary sources, spermidine is found in a variety of foods, including:

• Fresh peppers
• Wheat germ
• Broccoli
• Cauliflower
• Cheese
• Soy products like natto, shiitake, and durian

It’s also available as a dietary supplement, which can be a convenient way to increase your spermidine intake if you’re having trouble getting enough from your diet alone.

Overall, spermidine is a promising nutrient that has been shown to have many health benefits. Further research is needed to fully understand its effects, but current evidence suggests that it may be a valuable addition to a healthy Longevity Lifestyle.

The post Spermidine May Increase Human Healthspan appeared first on NOMIX.

Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effects associated with these molecules are additionally highlighted.

Links:

• The Sinclair Lab website
• Nicotinamide riboside is well-tolerated in humans
• Nicotinamide riboside is a sirtuin-activator
• Mice treated with nicotinamide riboside are longer-lived
• Nicotinamide riboside protects mice against obesity
• An inflammatory signature is attenuated by nicotinamide riboside
• Nicotinamide riboside, pterostilbene, and ALS
• Nicotinamide mononucleotide combats diabetes in mice
• Aging is slowed by nicotinamide mononucleotide
• Nicotinamide mononucleotide in prediabetic women
• NAD and cancer in mice
• Resveratrol protects mice against a high-calorie diet
• Resveratrol in patients with type 2 diabetes
• Supplementing resveratrol in metabolic syndrome patients
• Fisetin enhances longevity in mice
• Quercetin and fatty liver disease
• Dasatinib and quercetin decrease senescent cell burden
• Mice fed rapamycin late in life live longer
• Spermidine induces life extension and cardioprotection in mice
• Spermidine and older subjects with cognitive decline
• Healthspan and lifespan in mice are improved by metformin
• Metformin, age-related diseases, and mortality
• Targeting aging with metformin (TAME) trial
• Treating mice with berberine extends lifespan
• Lifespan in fruit flies is prolonged by berberine
• Berberine and metabolic disorders

The post Healthspan Supplements: NMN, NR, Resveratrol, Metformin & Other Longevity Molecules appeared first on NOMIX.