They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep.

Links:

• The cerebellum in the brain ages slowly
• Neuronal cells have a lower epigenetic age
• Sirt1 regulates aging in mice
• Mediterranean diet and brain health
• Mediterranean diet and dementia risk
• Aerobic exercise improves executive functioning
• Exercise and mouse models of neurodegenerative disease
• Strength exercises elevate the expression of BDNF
• Metformin enhances cognitive ability in fish
• Alzheimer’s disease and metformin
• Metformin use correlates with a reduced risk of dementia
• NAD boosting and Alzheimer’s disease
• ALS, nicotinamide riboside, and pterostilbene
• Vascular aging and NAD in mice
• In mice, overexpressing Sirt1 in the brain extends lifespan
• Sirt1 ameliorates amyotrophic lateral sclerosis in mice
• Sirt1 protects against Alzheimer’s disease in mice
• Sirt1 and neuroprotection in a mouse model of Huntington’s disease
• Sleep loss reduces lifespan in flies
• A single night of sleep deprivation increases amyloid-beta
• All-cause mortality correlates with sleep duration

The post The Science of Keeping the Brain Healthy appeared first on NOMIX.

Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effects associated with these molecules are additionally highlighted.

Links:

• The Sinclair Lab website
• Nicotinamide riboside is well-tolerated in humans
• Nicotinamide riboside is a sirtuin-activator
• Mice treated with nicotinamide riboside are longer-lived
• Nicotinamide riboside protects mice against obesity
• An inflammatory signature is attenuated by nicotinamide riboside
• Nicotinamide riboside, pterostilbene, and ALS
• Nicotinamide mononucleotide combats diabetes in mice
• Aging is slowed by nicotinamide mononucleotide
• Nicotinamide mononucleotide in prediabetic women
• NAD and cancer in mice
• Resveratrol protects mice against a high-calorie diet
• Resveratrol in patients with type 2 diabetes
• Supplementing resveratrol in metabolic syndrome patients
• Fisetin enhances longevity in mice
• Quercetin and fatty liver disease
• Dasatinib and quercetin decrease senescent cell burden
• Mice fed rapamycin late in life live longer
• Spermidine induces life extension and cardioprotection in mice
• Spermidine and older subjects with cognitive decline
• Healthspan and lifespan in mice are improved by metformin
• Metformin, age-related diseases, and mortality
• Targeting aging with metformin (TAME) trial
• Treating mice with berberine extends lifespan
• Lifespan in fruit flies is prolonged by berberine
• Berberine and metabolic disorders

The post Healthspan Supplements: NMN, NR, Resveratrol, Metformin & Other Longevity Molecules appeared first on NOMIX.

In this podcast episode, Andrew Huberman and David Sinclair discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process. They discuss (intermittent) fasting and supplementation with Resveratrol, Metformin, and NMN.

They also discuss the use of caffeine, exercise, cold exposure, along with food choices for offsetting aging and promoting autophagy, the process of clearing the organism of dead cells. And they discuss the key blood markers everyone should monitor to determine their biological versus chronological age.

It rarely happens that top scientists talk in easily understandable words and provide such a wealth of useful advice. We therefore strongly recommend listening to or even watching this podcast episode – these two hours might belong to the best investment of your valuable time, ever! Since – who does not want to stop aging?!

Enjoy!

The post Why We Age, And Why We Don’t Have To appeared first on NOMIX.